5-Amino-1MQ Overview

5-Amino-1MQ is a small-molecule compound primarily studied for its role as a nicotinamide N-methyltransferase (NNMT) inhibitor. NNMT is an enzyme involved in nicotinamide metabolism and methylation pathways, making 5-Amino-1MQ of interest in metabolic, epigenetic, and cellular energy research.

Due to its defined mechanism and reproducible activity, 5-Amino-1MQ is commonly referenced in laboratory models exploring metabolic regulation, methyl donor balance, and NAD⁺-related pathways.

Chemical Structure and Identification

• Chemical Name: 5-Amino-1-methylquinolinium iodide

• Common Name: 5-Amino-1MQ

• CAS Number: 685079-15-6

• Molecular Formula: C10H11N2-C

• Molecular Weight: 159.21 g/mol

5-Amino-1MQ is a quaternary quinolinium compound typically supplied as an iodide salt. The quaternary nitrogen and amino substitution contribute to its interaction with NNMT and related methylation processes.

Chemical identity and molecular data are verified using PubChem reference standards.

Mechanism of Action

5-Amino-1MQ functions as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor.

Inhibition of NNMT may influence:

• Nicotinamide metabolism

• Cellular methylation balance

• NAD⁺-related biochemical pathways

• Energy and metabolic signaling models

Its direct enzyme-level interaction makes 5-Amino-1MQ a useful tool in mechanistic metabolic research.

Research Applications

5-Amino-1MQ is commonly utilized in laboratory research involving:

• NNMT enzyme activity studies

• Metabolic regulation models

• Epigenetic and methylation pathway research

• Cellular energy and NAD⁺ signaling investigations

• Comparative NNMT inhibitor analysis

Its consistent biochemical behavior supports its use as a reference compound in NNMT-focused studies.

Physical and Chemical Properties

• Form: Solid compound (iodide salt)

• Solubility: Commonly prepared in polar solvents for laboratory use

• Stability: Stable under controlled storage conditions

Handling and preparation methods may vary depending on experimental design and solvent system.

Research Use Disclaimer

5-Amino-1MQ is provided strictly for laboratory research use only (RUO).
Not intended for human consumption, clinical use, veterinary use, or diagnostic purposes.
All research involving this compound must comply with applicable regulations and institutional guidelines.

Final Summary

5-Amino-1MQ is a well-defined NNMT inhibitor with a documented chemical structure and growing relevance in metabolic and epigenetic research. Its enzyme-targeted mechanism and reproducible activity make it a valuable compound for studying nicotinamide metabolism and methylation-related pathways.