Product | MOTS-C 20MG

MOTS-C 20MG

MOTS-C 20mg — Mitochondrial-derived retrograde signaling peptide (CAS 1627580-76-4). AMPK activator, exercise mimetic. 99% purity, USA domestic. Same-day shipping. Free shipping over $200.

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MOTS-C 20mg — Mitochondrial-Derived Research Peptide

MOTS-C 20mg delivers a mid-range research quantity of the mitochondrial-derived peptide (MDP) (CAS 1627580-76-4), the 16-amino acid retrograde signaling molecule encoded within the mitochondrial 12S rRNA region. The 20mg vial supports extended pre-clinical studies, multi-run experimental protocols, and dose-response curve development requiring greater compound volume than the 10mg entry vial. MOTS-C is studied for AMPK activation, insulin sensitivity, folate cycle modulation, exercise mimetic effects, and mitochondria-to-nucleus retrograde signaling — one of the most novel research areas in metabolic and longevity peptide science.

What Is MOTS-C?

  • Mitochondria-to-nucleus retrograde signaling — coordinates adaptive responses between mitochondria and nuclear gene expression
  • AMPK activation via AICAR — folate cycle inhibition drives AICAR accumulation and AMPK-mediated metabolic signaling
  • Insulin sensitivity — improves glucose uptake and insulin receptor signaling in skeletal muscle
  • Exercise mimetic — replicates exercise-induced metabolic adaptations in pre-clinical sedentary models
  • Longevity and healthspan — age-related metabolic decline and mitochondrial function models
  • Stress response adaptation — mitohormesis and cellular stress resilience research

Common Research Applications

MOTS-C 20mg (CAS 1627580-76-4) is used across professional pre-clinical research settings for:

  • Multi-run AMPK pathway activation and metabolic signaling studies
  • Extended dose-response curve development for insulin sensitivity research
  • Longitudinal mitochondrial retrograde signaling and mito-nuclear crosstalk studies
  • Exercise mimetic and physical performance pre-clinical modeling across multiple cohorts
  • Longevity pathway and healthspan multi-run experimental protocols
  • Comparative MOTS-C vs. humanin and SHLP mitochondrial peptide studies

Why Researchers Buy MOTS-C from Combat Research

Researchers searching for MOTS-C 20mg for sale or a trusted source to buy MOTS-C research peptide rely on Combat Research:

  • 99% purity — verified by third-party analytical testing
  • USA domestic stock — no international delays
  • Same-day shipping on all in-stock orders
  • Free shipping on orders over $200
  • 5% crypto discount available on every order

Chemical & Physical Properties

PropertyValue
CAS Number1627580-76-4
Also Known AsMOTS-c, Mitochondrial Open Reading Frame of the 12S rRNA-c
Amino Acids16 (MRWQEMGYIFYPRKLR)
Genome OriginMitochondrial 12S rRNA region (mtDNA-encoded)
Key PathwayAMPK, folate cycle, AICAR, mito-nuclear crosstalk
FormLyophilized Powder
Vial Size20mg
Purity≥99%
StorageRefrigerated, protected from light and moisture

Handling & Reconstitution

MOTS-C 20mg is supplied as a lyophilized powder. Reconstitute with bacteriostatic water or sterile saline under aseptic conditions. Store at 2–8°C. Minimize freeze-thaw cycles.

Research Use Only

MOTS-C (CAS 1627580-76-4) is sold exclusively for pre-clinical and in vitro laboratory research. Not for human or animal consumption. All use must comply with applicable regulations.

Frequently Asked Questions — MOTS-C 20MG

What is MOTS-C?

MOTS-C (CAS 1627580-76-4) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region. It acts as a retrograde signaling molecule studied for AMPK activation, insulin sensitivity, folate cycle modulation, exercise mimetic effects, and longevity pathway research.

What is MOTS-C 20mg best suited for?

MOTS-C 20mg is ideal for extended multi-run AMPK and insulin sensitivity studies, longitudinal dose-response protocols, multi-cohort exercise mimetic research, and established programs requiring more compound volume than the 10mg entry vial without committing to the 40mg bulk quantity.

What is the CAS number for MOTS-C?

CAS 1627580-76-4. Sequence: MRWQEMGYIFYPRKLR (16 amino acids). Encoded in the mitochondrial 12S rRNA region.

How does MOTS-C activate AMPK?

MOTS-C inhibits the folate cycle, leading to AICAR accumulation. AICAR is a direct AMPK activator, linking mitochondrial metabolic status to whole-cell energy sensing and triggering downstream glucose uptake, fatty acid oxidation, and mitochondrial biogenesis pathways.

What is the difference between MOTS-C 10mg, 20mg, and 40mg?

MOTS-C 10mg suits pilot studies and protocol validation. MOTS-C 20mg supports extended multi-run protocols and mid-range dose-response development. MOTS-C 40mg provides the best per-milligram value for high-throughput, long-duration, or multi-cohort research programs.

How do you reconstitute MOTS-C 20mg?

Reconstitute with bacteriostatic water or sterile saline under aseptic conditions. Gently swirl until dissolved. Store at 2-8 degrees Celsius. Minimize freeze-thaw cycles.

Where can I buy MOTS-C 20mg research peptide?

MOTS-C 20mg is available from Combat Research with 99% purity, USA domestic stock, same-day shipping, and free shipping on orders over .

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