FOR RESEARCH PURPOSES ONLY NOT FOR HUMAN USE. THESE ARE NOT MEDICAL CLAIMS.
Gastric pentadecapeptide BPC-157 (also known as Body Protection Compound 157, bepecin, or PL 14736) is a synthetic fifteen amino acid oligopeptide derived from a protein found in human gastric juice. BPC-157 has been studied primarily in laboratory animals. BPC-157 is not approved by any drug regulatory agency for human use, and there is limited data regarding its effectiveness on humans.
The peptide has gained popularity among athletes and the general public for injury recovery, leading the World Anti-Doping Agency to ban it in 2022. Health authorities discourage its use due to insufficient human safety data, and some jurisdictions have restricted it as a prescription-only medicine despite it not being available through legitimate prescriptions. Additionally, because the compound promotes blood vessel formation (angiogenesis), there are theoretical concerns about potential cancer promotion that require further investigation.
The peptide was discovered during research on human gastric juice.[2] The amino acid sequence is Gly–Glu–Pro-Pro-Pro-Gly-Lys-Pro-Ala–Asp-Asp-Ala-Gly-Leu–Val.[3] BPC-157 is stable at room temperature and bioavailable in rodent models when administered IM or IV.[1] The peptide demonstrates unusual stability in human gastric juice, remaining intact for more than 24 hours.[4]
Research
Pre-clinical research has indicated that BPC-157 may have cytoprotective, neuroprotective, and anti-inflammatory effects, and may also accelerate tissue and organ healing.[5][6][4][7][8]
This substance is sometimes used in functional medicine despite not being approved by any drug regulatory agency.[9] The compound promotes angiogenesis and as a result has some concerns over cancer promotion.[10]
As of 2022, the peptide has been banned by the World Anti-Doping Agency under the S0 category of non-exempt substances.[11][12]
BPC-157 has been widely used both by athletes and among the general public, mainly for recovery from injury or stimulating healing in chronic conditions,[13][14][15][16] but there is as yet only very limited human trial data on efficacy and only a few preliminary safety studies,[17][18][19] so use of BPC-157 is discouraged by health authorities and it has been controlled as a prescription medicine in several jurisdictions such as New Zealand and Australia, despite not actually being available for prescription.
