CombatResearch.is | For Research Use Only | Not for Human Consumption
Overview
CJC-1295 is a synthetic GHRH analog and growth hormone secretagogue (GHS) used in peptide research. Like all research-grade compounds, it demands precise handling, accurate documentation, and strict adherence to safety protocols. This guide covers compound identification, SDS interpretation, PPE requirements, handling and reconstitution, storage, spill response, and recordkeeping for compliant laboratory use.
All information in this guide is intended for qualified researchers operating within an institutional research environment. This material is for research use only.
Compound Identification
CJC-1295 is available in two distinct variants. You must confirm which version you are working with before beginning any experiment — the two forms have different structural profiles and are not interchangeable in research protocols.
CJC-1295 with DAC (Drug Affinity Complex) The DAC modification extends the compound’s half-life by enabling albumin binding. Use the following data for logbook entry and CoA verification:
| Parameter | Detail |
|---|---|
| Variant | CJC-1295 with DAC |
| CAS Number | 446262-90-4 |
| Molecular Formula | C₁₅₄H₂₅₆N₄₄O₄₄ |
| Molecular Weight | 3,427.9 g/mol |
| Physical Form | Lyophilized powder; white to off-white solid |
CJC-1295 without DAC (Modified GRF 1-29) The non-DAC variant lacks the albumin-binding modification, resulting in a shorter active profile. Verify the CAS number and molecular weight on the CoA against your specific batch documentation.
Three-Way Verification Protocol Upon receipt, place the vial, the Safety Data Sheet (SDS), and the Certificate of Analysis (CoA) side by side. The compound name, CAS number, and batch number must be identical across all three documents. If there is any discrepancy, do not use the material — contact your supplier immediately. This verification step is mandatory before any material enters your research workflow.
Understanding Your SDS
The Safety Data Sheet is your primary safety reference for every compound in the lab. It is also a legal document demonstrating your facility’s compliance with standard safety regulations. CombatResearch.is provides a batch-specific SDS with every order — do not substitute a generic version downloaded from the internet. The SDS must correspond to your specific batch.
Read the SDS in full before opening any vial. Key sections to review first:
- Section 1 — Identification: Confirm the product name and “For Research Use Only” designation
- Section 2 — Hazards Identification: Review hazard pictograms and GHS classifications
- Section 3 — Composition: Verify compound identity and stated purity
- Section 7 — Handling and Storage: Review baseline safe handling requirements
- Section 8 — Exposure Controls / PPE: Confirm required protective equipment for your specific handling conditions
Keep a printed copy of the SDS at your workstation during all handling sessions.
Hazard Classification and Toxicology
GHS classification for CJC-1295 varies across supplier documentation. Some SDSs classify the compound as not meeting formal GHS hazard criteria; others assign a warning classification indicating potential irritant or health hazard status under improper handling conditions.
The absence of a formal GHS classification does not indicate that a compound is proven safe — it indicates that available data did not meet the threshold for a formal label assignment. For synthetic peptides with limited toxicological datasets, the precautionary principle applies: assume potential risk and use the highest appropriate safety standards regardless of classification status.
Do not extrapolate from missing data. Treat gaps in toxicological information as a reason for increased caution, not reduced caution.
Personal Protective Equipment (PPE)
PPE requirements should be based on two documents in this order: your facility’s Standard Operating Procedures (SOPs), and the batch-specific SDS from your supplier.
Standard PPE for CJC-1295 handling:
- Lab coat — physical barrier between compound and skin/clothing
- Chemical-resistant gloves — nitrile minimum; verify compatibility with any solvents used in reconstitution
- Safety glasses or goggles — protection against accidental aerosol or splash
- Respirator — required when handling loose lyophilized powder outside a fume hood environment; fine peptide particles can become airborne during weighing
The goal is complete exposure prevention. When in doubt, upgrade your PPE rather than reduce it.
Workspace and Engineering Controls
Prepare a designated handling area before opening any material. Select a clean, stable bench surface in a low-traffic zone to minimize the risk of accidental contact or displacement.
Handle all dry lyophilized powder inside a chemical fume hood. The hood’s directional airflow pulls airborne particles away from the researcher and prevents room contamination. This is the most effective engineering control available for powder handling.
Do not handle loose powder near open windows, HVAC vents, or fans. Even minor air movement can disperse fine peptide particles across the workspace.
Handling and Reconstitution Protocol
Pre-use inspection: Examine the vial before use. Check for cracks, compromised seals, or loose caps. Inspect the powder — discoloration or visible moisture are indicators of degradation. Do not use suspect material; document the observation and contact your supplier.
Reconstitution steps:
- Allow the frozen vial to equilibrate to room temperature — approximately 15–20 minutes
- Wipe the rubber stopper with a 70% isopropyl alcohol swab; allow to dry
- Draw the appropriate volume of sterile solvent (typically bacteriostatic water for CJC-1295 research applications) into a sterile syringe
- Insert the needle at an angle and deliver the solvent slowly along the inner glass wall — do not inject directly onto the lyophilized cake
- Gently swirl the vial to mix — do not vortex or shake vigorously
- Allow complete dissolution before proceeding; do not force undissolved material into solution
Careless reconstitution technique is one of the most common sources of material degradation. Take the time to do it correctly.
Storage and Stability
Lyophilized peptides are sensitive to heat, moisture, light, and air. Proper storage is not optional — degraded material produces unreliable data.
| Storage Condition | Temperature |
|---|---|
| Long-term (lyophilized) | −20°C, sealed, away from light |
| Short-term (lyophilized) | 2°C to 8°C, up to 4 weeks |
| Reconstituted solution | 2°C to 8°C; use within 28 days; avoid repeat freeze-thaw |
Use amber vials where possible. Keep containers tightly sealed between uses.
Label every vial immediately upon receipt or reconstitution. Labels must include:
- Compound name and variant (e.g., “CJC-1295 DAC”)
- Date of receipt or reconstitution
- Concentration (if in solution)
- Researcher initials
- Batch number
Unlabeled vials are a compliance failure and a data integrity risk.
Spill Response and Exposure Protocols
Spill response:
- Alert nearby personnel immediately to establish a perimeter around the affected area
- For dry powder: cover with a damp cloth or absorbent material to prevent airborne dispersal; do not sweep
- For liquid spill: apply absorbent pads; work from the outside of the spill inward
- Collect all contaminated material in a sealed waste container
- Dispose of as chemical waste per your facility’s waste disposal protocols — never in standard trash or drain
Skin contact: Wash affected area with soap and water for a minimum of 15 minutes. Seek medical evaluation.
Eye contact: Flush with clean water for a minimum of 15 minutes, holding eyelids open. Seek immediate medical attention.
Inhalation: Remove to fresh air immediately. Seek medical evaluation if symptoms persist.
All exposure incidents must be reported to your supervisor and documented in an incident report. Incident records support future risk assessment and demonstrate regulatory compliance.
Recordkeeping and Compliance
Accurate records are the evidence that your research is professional, safe, and legally compliant. During audits, your documentation is your defense.
Maintain the following logs throughout the research project:
Storage condition log — Record storage temperature and condition checks by date. Flag any deviations immediately.
Access and usage log — Record the date, researcher name, amount used, and remaining balance every time the material is accessed. This prevents unaccounted losses and confirms the compound remained within the controlled research environment.
Training records — File signed acknowledgment documents for every authorized personnel member, including the date training was completed and the specific compound covered.
Retain all records for a minimum of three to five years, or per your institutional policy if longer. These records are your primary evidence during any regulatory review.
All vials, documentation, and communications must carry the “For Research Use Only” designation. This label is a legal control, not a formality.
Research Compound Disclaimer
For Research Use Only. Not for Human Consumption. Not for Veterinary Use.
CJC-1295 supplied by CombatResearch.is is intended exclusively for in vitro and preclinical research applications by qualified researchers and institutions. It has not been evaluated by the FDA for safety or efficacy in humans. It is not approved as a drug, dietary supplement, or food additive. Purchase constitutes acknowledgment that the buyer will use the material solely within the bounds of applicable research regulations.
CombatResearch.is — Research Grade. Verified Purity. Compliant Supply.
