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GLP-1 5mg

Semaglutide 5mg (GLP-1) — GLP-1 receptor agonist research peptide (CAS 910463-68-2). Same compound as Ozempic/Wegovy. 99% purity, USA domestic. Same-day shipping. Free shipping over $200.

Original price was: $70.00.Current price is: $37.99.

156 in stock (can be backordered)

CERTIFICATE OF ANALYSIS

CERTIFICATE OF ANALYSIS

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Semaglutide 5mg (GLP-1) — GLP-1 Receptor Agonist Research Peptide

Semaglutide 5mg — sold under the GLP-1 category — is a research-grade synthetic GLP-1 receptor agonist (CAS 910463-68-2, C187H291N45O59, 4113.58 g/mol) with 94% sequence homology to native human Glucagon-Like Peptide-1. Semaglutide incorporates a C18 fatty diacid side chain attached via a hydrophilic linker to Lys26, enabling albumin binding that extends plasma half-life to approximately 7 days — the mechanism underlying its FDA-approved pharmaceutical forms Ozempic®, Wegovy®, and Rybelsus®. The 5mg vial provides an optimal quantity for GLP-1R binding assays, pilot dose-response studies, and receptor selectivity research.

What Is Semaglutide (GLP-1 Receptor Agonist)?

Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein coupled receptor expressed across multiple tissues with broad research relevance:

  • Pancreatic beta cells — glucose-dependent insulin secretion stimulation and beta-cell preservation research
  • Hypothalamus & brainstem — appetite suppression, satiety signaling, and energy homeostasis pathway studies
  • Cardiovascular tissue — cardioprotective signaling, heart rate, and vascular function models
  • Liver — hepatic glucose output modulation and lipid metabolism research
  • Kidney — renal GLP-1R expression and nephroprotective pathway investigations

Common Research Applications

Semaglutide 5mg (GLP-1, CAS 910463-68-2) is utilized in professional pre-clinical research settings for:

  • GLP-1 receptor binding affinity and activation assays
  • Insulin secretion and beta-cell function signaling studies
  • Hypothalamic appetite and energy homeostasis pathway research
  • Cardiovascular GLP-1R signaling and cardioprotection models
  • Comparative agonist studies: semaglutide vs. tirzepatide vs. retatrutide (GLP-3)
  • Fatty acid side chain albumin-binding pharmacokinetic research
  • Metabolic syndrome, obesity, and T2 diabetes pre-clinical models

Why Researchers Buy Semaglutide from Combat Research

When searching for semaglutide 5mg for sale or a trusted source to buy semaglutide research peptide online, researchers choose Combat Research for analytical quality and reliable US fulfillment:

  • 99% purity — verified by third-party analytical testing
  • USA domestic stock — no international delays or customs risk
  • Same-day shipping on all in-stock orders
  • 2–3 day average delivery across the continental US
  • Free shipping on orders over $200
  • 5% crypto discount available on every order
  • Lyophilized for stability — maintains C18 side chain integrity through storage and transit

Chemical & Physical Properties

PropertyValue
CAS Number910463-68-2
Also Known AsSemaglutide, GLP-1 agonist, Ozempic (brand), Wegovy (brand), Rybelsus (brand)
Molecular FormulaC187H291N45O59
Molecular Weight4113.58 g/mol
Receptor TargetGLP-1R (Glucagon-Like Peptide-1 Receptor)
Plasma Half-Life~7 days (albumin-bound via C18 fatty diacid)
Sequence Homology94% to native human GLP-1
FormLyophilized Powder
Vial Size5mg
Purity≥99%
StorageRefrigerated, protected from light and moisture

Semaglutide vs. Tirzepatide vs. Retatrutide (GLP-3)

Understanding GLP receptor agonist coverage is essential for choosing the right compound for your research design:

CompoundReceptor TargetsAgonist Type
Semaglutide (GLP-1)GLP-1RSingle agonist
TirzepatideGLP-1R + GIPRDual agonist
Retatrutide (GLP-3)GLP-1R + GIPR + Glucagon RTriple agonist

Handling & Reconstitution

Semaglutide 5mg is supplied as a lyophilized (freeze-dried) powder. Reconstitute with bacteriostatic water or sterile saline under aseptic laboratory conditions prior to experimental use. Store reconstituted solution refrigerated at 2–8°C. Minimize freeze-thaw cycles to preserve the C18 fatty diacid side chain and albumin-binding properties.

Research Use Only

Semaglutide (CAS 910463-68-2) is sold exclusively for pre-clinical and in vitro laboratory research. This product is not for human or animal consumption outside of FDA-approved clinical indications. All research use must comply with applicable local, state, and federal regulations governing research compounds.

Frequently Asked Questions — GLP-1 5mg

What is Semaglutide (GLP-1)?

Semaglutide (CAS 910463-68-2, C187H291N45O59, 4113.58 g/mol) is a synthetic GLP-1 receptor agonist with 94% sequence homology to native human GLP-1. It is modified with a C18 fatty diacid chain via a linker for albumin binding, extending plasma half-life to approximately 7 days. It is studied for GLP-1R activation, insulin secretion signaling, and metabolic pathway research.

Is Semaglutide the same as Ozempic or Wegovy?

Semaglutide is the active compound in Ozempic (diabetes management), Wegovy (weight management), and Rybelsus (oral formulation) – all FDA-approved brand-name drugs. The research peptide semaglutide (CAS 910463-68-2) is the same molecule sold strictly for pre-clinical laboratory research use only.

What receptors does Semaglutide target?

Semaglutide is a selective GLP-1 receptor (GLP-1R) agonist. GLP-1R is expressed in pancreatic beta cells, hypothalamus, brainstem, liver, heart, and kidney, enabling multi-tissue research into insulin secretion, appetite regulation, cardiovascular signaling, and metabolic homeostasis.

How is Semaglutide different from tirzepatide or retatrutide?

Semaglutide is a single GLP-1R agonist. Tirzepatide is a dual GLP-1/GIP agonist. Retatrutide (GLP-3) is a triple GLP-1/GIP/glucagon agonist. Each offers different receptor coverage for metabolic research. Semaglutide provides the most GLP-1R selective research profile.

What is the CAS number for Semaglutide?

CAS 910463-68-2. Molecular formula C187H291N45O59, molecular weight 4113.58 g/mol. PubChem CID 56843331. ChEMBL ID CHEMBL3301622.

How do you reconstitute Semaglutide research peptide?

Reconstitute with bacteriostatic water or sterile saline under aseptic conditions. Gently swirl until dissolved. Store refrigerated at 2-8 degrees Celsius and minimize freeze-thaw cycles to preserve the C18 fatty acid side chain integrity.

What is Semaglutide 5mg best suited for in research?

Semaglutide 5mg is ideal for GLP-1R binding and activation assays, pilot dose-response studies, receptor selectivity comparisons, and protocol development where a moderate compound quantity is required without committing to bulk volume.

Scientific References & Further Reading

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