IGF-1 LR3 1mg — Long Arg3 IGF-1 research peptide (CAS 946870-92-4). 20-30hr half-life, minimal IGFBP binding. 99% purity, USA domestic. Same-day shipping. Free shipping over $200.
Original price was: $100.00.$69.99Current price is: $69.99.
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IGF-1 LR3 1mg is a research-grade modified analog of Insulin-Like Growth Factor-1 (IGF-1) (CAS 946870-92-4, ~9117 g/mol) engineered for dramatically extended biological activity compared to native IGF-1. The LR3 modification consists of two changes: substitution of Glu3 with Arg3 (reducing IGF binding protein affinity) and addition of a 13-amino acid N-terminal extension (MFPAMPLLSLFVNGPRTSL-) that further disrupts IGFBP binding. The result is a plasma half-life of 20–30 hours (vs. ~10–15 minutes for native IGF-1), enabling sustained IGF-1R activation studies without the rapid clearance limitations of the native molecule.
| Property | IGF-1 LR3 | Native IGF-1 |
|---|---|---|
| Plasma Half-Life | 20-30 hours | ~10-15 minutes |
| IGFBP Binding | Minimal (Arg3 + N-ext) | High (sequestered by IGFBPs) |
| IGF-1R Potency | Comparable to native | Standard |
| Amino Acids | 83 (70 IGF-1 + 13 N-ext) | 70 |
IGF-1 LR3 1mg (CAS 946870-92-4) is used in professional pre-clinical research settings for:
When searching for IGF-1 LR3 1mg for sale or a trusted source to buy IGF-1 LR3 research peptide, researchers choose Combat Research:
| Property | Value |
|---|---|
| CAS Number | 946870-92-4 |
| Also Known As | IGF-1 LR3, Long R3 IGF-1, Long Arg3 Insulin-Like Growth Factor-1 |
| Molecular Weight | ~9117 g/mol |
| Amino Acids | 83 (70 IGF-1 + 13 N-terminal extension) |
| Key Modifications | Arg3 substitution, 13-aa N-terminal extension |
| Plasma Half-Life | 20-30 hours |
| Form | Lyophilized Powder |
| Vial Size | 1mg |
| Purity | ≥99% |
| Storage | Refrigerated, protected from light and moisture |
IGF-1 LR3 1mg is supplied as a lyophilized powder. Reconstitute with dilute acetic acid (0.1% acetic acid) or bacteriostatic water under aseptic conditions. Store at 2–8°C. Minimize freeze-thaw cycles.
IGF-1 LR3 (CAS 946870-92-4) is sold exclusively for pre-clinical and in vitro laboratory research. Not for human or animal consumption. All use must comply with applicable regulations.
IGF-1 LR3 (Long Arg3 IGF-1, CAS 946870-92-4) is a modified 83-amino acid analog of IGF-1 with two key changes: Arg3 substitution (replacing Glu3) and a 13-amino acid N-terminal extension. These modifications reduce IGF binding protein (IGFBP) affinity, extending plasma half-life to 20-30 hours vs. ~10-15 minutes for native IGF-1.
Native IGF-1 has a ~10-15 minute plasma half-life due to rapid IGFBP sequestration. IGF-1 LR3 has an Arg3 substitution and 13-aa N-terminal extension that dramatically reduce IGFBP binding, extending half-life to 20-30 hours. This enables sustained IGF-1R signaling research without rapid clearance limitations.
CAS 946870-92-4. Also known as Long R3 IGF-1 and Long Arg3 Insulin-Like Growth Factor-1. MW ~9117 g/mol. 83-amino acid modified IGF-1 analog.
IGF-1 LR3 activates IGF-1R (IGF-1 receptor), triggering the PI3K/Akt/mTOR pathway (cell survival, protein synthesis, hypertrophy) and the MAPK/ERK pathway (cell proliferation and differentiation). It is widely used in muscle cell hypertrophy, anti-apoptotic signaling, and cell growth research.
IGF-1 LR3 is studied for IGF-1R activation and sustained downstream signaling, skeletal muscle hypertrophy and satellite cell activation, cell line proliferation and differentiation assays, anti-apoptotic Akt pathway research, comparative IGF-1 analog pharmacology, and protein synthesis pathway studies.
Reconstitute IGF-1 LR3 with 0.1% acetic acid or bacteriostatic water under aseptic conditions. Gently swirl until dissolved. Store at 2-8 degrees Celsius. Minimize freeze-thaw cycles. Note: acetic acid reconstitution is recommended for optimal solubility.
IGF-1 LR3 1mg is available from Combat Research with 99% purity, USA domestic stock, same-day shipping, and free shipping on orders over .
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