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Non-Peptide Growth Hormone Secretagogue | Research Use Only
MK-677, also known as Ibutamoren, is a non-peptide, small-molecule growth hormone secretagogue extensively studied in laboratory and clinical research for its ability to stimulate endogenous growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion. It exerts its effects through selective activation of the ghrelin receptor (GHS-R1a).
Unlike peptide-based GHRPs, MK-677 is orally active in research models, making it a foundational compound in studies involving long-term endocrine signaling, metabolic regulation, and GH/IGF-1 axis modulation.
MK-677 is supplied strictly for laboratory and analytical research purposes only and is not approved for human or veterinary use.
In experimental research models, MK-677 functions as a selective ghrelin receptor agonist. Activation of GHS-R1a has been shown to result in:
Increased pulsatile growth hormone secretion
Elevated circulating IGF-1 levels
Modulation of appetite-related and metabolic signaling pathways
MK-677 does not act as growth hormone itself. Instead, it stimulates upstream GH release, making it valuable for research into endocrine feedback loops and GH axis regulation.
MK-677 is a thio-containing, non-peptide small molecule, commonly supplied as a mesylate salt. Its structure enables high-affinity ghrelin receptor binding while maintaining metabolic stability in experimental systems.
Structural and molecular data are indexed in PubChem and other chemical databases.
Appearance: White to off-white crystalline powder
Solubility: Soluble in organic solvents; limited aqueous solubility
Stability: Stable when stored dry, cool, and protected from light
MK-677 (Ibutamoren) is widely examined in laboratory research involving:
Growth hormone & IGF-1 axis regulation
Ghrelin receptor signaling pathways
Endocrine and metabolic research models
Muscle, bone, and aging-related signaling studies
Long-term GH secretion dynamics
Dry-Fill Capsules: 10 mg
All products are clearly labeled and supplied to research-grade standards.
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⚠️ Research Use Only (RUO).
MK-677 (Ibutamoren) is not for human consumption, medical use, or diagnostic application.
Not a drug. Not a dietary supplement.
All handling and use must comply with applicable laws, regulations, and laboratory safety standards.
| Specification | Details |
|---|---|
| Compound Name | Ibutamoren Mesylate |
| Other Names | MK-677, MK-0677, L-163,191, Oratrope |
| CAS Number | 159634-47-6 |
| IUPAC Name | 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide mesylate |
| Molecular Formula | C₂₈H₄₀N₄O₈S₂ |
| Molecular Weight | 624.77 g/mol |
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