MOTS-C 10mg — Mitochondrial-derived retrograde signaling peptide (CAS 1627580-76-4). AMPK activator, exercise mimetic. 99% purity, USA domestic. Same-day shipping. Free shipping over $200.
$42.99
165 in stock
MOTS-C 10mg is a research-grade mitochondrial-derived peptide (MDP) (CAS 1627580-76-4), a 16-amino acid signaling peptide encoded within the 12S ribosomal RNA (rRNA) region of the mitochondrial genome (mtDNA). MOTS-C is one of the first discovered mitochondrially-encoded peptides, representing a novel class of retrograde mitochondria-to-nucleus signaling molecules. Research has demonstrated roles in metabolic regulation, insulin sensitivity, exercise mimetics, and longevity pathway activation via AMPK and folate cycle modulation. The 10mg vial is ideal for pilot studies and initial MOTS-C pathway investigations.
MOTS-C 10mg (CAS 1627580-76-4) is used in professional pre-clinical research for:
When searching for MOTS-C 10mg for sale or a trusted source to buy MOTS-C research peptide online, researchers choose Combat Research:
| Property | Value |
|---|---|
| CAS Number | 1627580-76-4 |
| Also Known As | MOTS-c, Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Amino Acids | 16 (MRWQEMGYIFYPRKLR) |
| Genome Origin | Mitochondrial 12S rRNA region (mtDNA-encoded) |
| Key Pathway | AMPK, folate cycle, AICAR, mito-nuclear crosstalk |
| Form | Lyophilized Powder |
| Vial Size | 10mg |
| Purity | ≥99% |
| Storage | Refrigerated, protected from light and moisture |
MOTS-C 10mg is supplied as a lyophilized powder. Reconstitute with bacteriostatic water or sterile saline under aseptic conditions. Store at 2–8°C. Minimize freeze-thaw cycles.
MOTS-C (CAS 1627580-76-4) is sold exclusively for pre-clinical and in vitro laboratory research. Not for human or animal consumption. All use must comply with applicable regulations.
MOTS-C (CAS 1627580-76-4) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It functions as a retrograde signaling molecule between mitochondria and the nucleus, studied for AMPK activation, insulin sensitivity, folate cycle modulation, exercise mimetic effects, and longevity pathway research.
MOTS-C is studied for mitochondria-to-nucleus retrograde signaling, AMPK pathway activation, insulin sensitivity enhancement in skeletal muscle models, folate cycle and one-carbon metabolism modulation, exercise mimetic effects in sedentary pre-clinical models, and longevity and healthspan research.
CAS 1627580-76-4. Sequence: MRWQEMGYIFYPRKLR (16 amino acids). Encoded within the mitochondrial 12S rRNA region of the mitochondrial genome. PubChem CID: 139585108.
MOTS-C inhibits the folate cycle, leading to accumulation of AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), a well-established AMPK activator. This mechanism links mitochondrial metabolic status to whole-cell energy sensing via the AMPK pathway.
Both MOTS-C and humanin are mitochondrially-derived peptides (MDPs). Humanin is encoded in the 16S rRNA region and primarily studied for cytoprotection and neuroprotection. MOTS-C is encoded in the 12S rRNA region and primarily studied for metabolic regulation, insulin sensitivity, and exercise mimetic effects.
Reconstitute with bacteriostatic water or sterile saline under aseptic conditions. Gently swirl until dissolved. Store at 2-8 degrees Celsius. Minimize freeze-thaw cycles.
MOTS-C 10mg is ideal for pilot AMPK pathway studies, initial dose-response development, mito-nuclear crosstalk assays, and protocol validation before committing to higher-volume research programs.
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